Top commercial, residential real estate deals of the week | TribLIVE

By Sam Spatter

Published: Saturday, December 1, 2012, 9:02?p.m.
Updated 20 hours ago

DEALSOF THE WEEK

A quick look at recent retail, commercial and industrial projects, sales and leases of note in Western Pennsylvania:

$4.7 million (combined price)

Properties sold: 922 Brush Creek Rd., Cranberry; 14200 Rt. 30, North Huntingdon.

Seller: Bridge Construction, Pittsburgh

Buyer: Guardian Storage Solutions, Pittsburgh

Details: Two Lock-Up Storage Centers, with Cranberry having 511 storage units and North Huntingdon, 411 storage units.

Comment: ?Bridge Construction built our local storage units, and decided to sell these two to us, giving us locations in areas we did not previously have,? said Steven H. Cohen, Guardian owner/president.

$3.9 million

Property sold: 610 Alpha Dr., RIDC Park, O?Hara

Seller: Regional Industrial Development Corp., Pittsburgh

Buyer: Penhurst Realty II LP, a unit of Tsudis Chocolate Co., Pittsburgh

Details: Acquired building it has occupied, following receipt of a $1.56 million loan from Pennsylvania Industrial Development Authority, which allowed Tsudis to reconfigure space for expansion, hire 75 employees for a total of 275.

Comment: ?Tsudis Chocolate had been leasing the building and decided to buy it, and make some improvements as it expands its operation there,? said Don Smith, Jr., RIDC president.

$2 million

Property sold: 150 Lake Dr., McCandless

Seller: Frank and Virginia Pelly, Pittsburgh

Buyer: Lake Drive Realty Partners LLC, Pittsburgh

Details: Two-story, 26,650-square-foot building, 90 percent leased.

Comment: ?A group of local investors purchased the building as an investment, and I still have 6,400 square feet available for lease,? said Jessica Jarosz of Colliers International/Pittsburgh who worked with Paul Fedorko of Marcus & Millichap?s Pittsburgh office who represented the seller.

TOP DOLLAR HOMES

Recent home and condominium sales that brought top prices in Western Pennsylvania:

$675,000

Property: North Strabane

Seller: William Ripper

Buyer: Perry and Kyle Dick

Details: Custom brick and stone Provincial, on 5.25 acres, two-story family room with wall of windows, stone fireplace, private den with French doors, master suite with Corian counters, jet tub, his-and-her vanities, extended level aggregate driveway and parking pad.

Comment: ?The buyers loved that this was in a private five-acre setting, yet close to Donaldson?s Crossroads. They liked the floor plan, two-story family room, huge gourmet maple kitchen and first floor master suite,? said Tim Ulam with Sue Franz of Coldwell Banker Real Estate.

$642,500

Property: Adams

Seller: Christopher Schueller

Buyer: Michael and Jennifer Zatchey

Detaisl: Brick Provincial with open family room, paneled study with built-in bookcases, mud room with large pantry, five bedrooms, four and a half baths, second-floor laundry, patio off kitchen/family room.

Comment: ?Buyers loved the neighborhood and flat back year, yet wooded, liked the finished lower level with a media room, the bedroom and the ?school room? for children,? said Kim Marie Angiulli, Coldwell Banker Real Estate.

$580,000

Property: Point Breeze

Seller: Sidney and Sylvia Busis

Buyer: Jeffrey Peterson and Roberta Miller

Details: Contemporary-style house on a cul de sac with second-floor office, all bedrooms with vaulted ceilings, shower for pet or clean off muddy feet, private back yard with patio, two-car garage with extra wide driveway.

Comment: ?Buyers found this a wonderful home, built by and loved by the sellers. They loved the contemporay archecture with great space and spacious indoor,? said Tamara Skirboll, Coldwell Banker Real Estate.

Sam Spatter is a staff writer for Trib Total Media. He can be reached at 412-320-7843 or sspatter@tribweb.com.

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Source: http://triblive.com/business/realestate/3025354-74/pittsburgh-seller-buyer-comment-details-property-building-family-floor-loved

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The Daily Roundup for 12.01.2012

You might say the day is never really done in consumer technology news. Your workday, however, hopefully draws to a close at some point. This is the Daily Roundup on Engadget, a quick peek back at the top headlines for the past 24 hours -- all handpicked by the editors here at the site. Click on through the break, and enjoy.

Continue reading The Daily Roundup for 12.01.2012

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Source: http://www.engadget.com/2012/12/01/the-daily-roundup-for-12-01-2012/

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Kngine Aims To Build A Natural Language-Driven App That Can Answer Any Question

Kngine (pronounced kin-gin, short for knowledge engine) is one of those startups with a goal that's both straightforward and impressively ambitious ? it wants to build an app that can answer any question. In fact, when you open the app, it prompts you to "ask me anything." When I watched the promotional video (embedded below), the first thing I thought of was Apple's Siri. And while Kngine co-founder and CEO Haymad ElFadeel doesn't shy away from the Siri comparison, he also said Kngine has a slightly different goal. One of Siri's big selling points is allowing you to access a lot of the iPhone's functions through voice, so when your questions are more fact- then task-based (i.e., Kngine's strong point) it relies on Wolfram Alpha.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/K5F2BkjlEN8/

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TEDxWomen 2012 Conference Will Reach Worldwide Audience

Hosted by Pat Mitchell and the Paley Center, TEDxWomen 2012 inspires women to raise their voices and be heard

WASHINGTON, Nov. 30, 2012 /PRNewswire-USNewswire/ --?Hosted by Pat Mitchell and The Paley Center for Media, TEDxWomen 2012 will take place November 30 and December 1, at the United States Institute for Peace in Washington, DC, and will be live streamed to 150 locally organized TEDx communities around the world.??

New this year, TEDxWomen and the Paley Center will offer the broadcast of the conference to the U.S. Department of State's embassies and more than 800 American Spaces around the world. ?American Spaces are public access venues where Americans and host country citizens come together for discussions on U.S. policy, society and values. Access to the TEDxWomen 2012 Conference enables people both in and outside of capital cities worldwide to connect to inspiring and sometimes surprising stories and ideas by and for women.

TEDxWomen 2012 will bring together a diverse group of talented and rousing women and men to challenge traditional gender roles and spotlight groundbreaking advances in topics ranging from autism to violence against women.? What makes TEDxWomen 2012 powerful is the fact it is designed to grow and expand organically, with each individual event acting as a catalyst for communities worldwide to create their own TEDxWomen events.

Events have already sprouted up in places like the Sudan, where TEDxKhartoumWomen?gives Sudanese women a platform to share their outstanding contributions to their community. Marieme Jamme in West Africa is introducing the TED concept to West Africans and planting the seeds for TED conferences in Accra. And Jamara Wakefield, a college student in an underserved area of Boston, has organized a TEDxRoxbury Women event, integrating spoken word artists into the traditional TED format.

"TEDxWomen has the power to change communities, and when linked together, change the world," said Pat Mitchell, CEO and President of The Paley Center for Media. "Now, more than ever, women have seen their collective power when they work together, share ideas, and elevate each other's voices."

"Bringing TEDxWomen to overseas audiences, many of whom would never be exposed to the original and creative thinking of the presenters, provides an engaging centerpiece for local events at U.S. Embassies and American Spaces that address such important policy issues as human rights, women's economic empowerment, and violence against women," said Dawn L. McCall, Coordinator of the Bureau of International Information Programs at the Department of State.

This year's speakers at TEDxWomen 2012 include:

• Julia Bluhm and Izzie Labbe: two young women who successfully petitioned Seventeen magazine to stop altering face and body shapes of girls with Photoshop.
• Anita Sarkeesian: a feminist media critic who initiated a successful Kickstarter campaign to examine gender tropes in video games. Shortly after, a Flash game, where users could punch a likeness of Sarkeesian, went viral, underscoring the sexism she sought to unveil.
• Bob Woodruff: a former ABC war correspondent who suffered a traumatic brain injury while embedded in Iraq, and his wife, Lee, who will describe their journey of starts and stops.
• Eve Ensler: a well-known feminist playwright, performer, writer, activist, and author of the The Vagina Monologues.
• Chung Hyun Kyung:? a Korean spiritual leader and ecofeminist.
• Musimbi Kanyoro: head of Global Fund for Women.
• Jessica Pabon: on the history of graffiti artists.

TEDxWomen is an independently organized event, licensed by TED. TEDxWomen is sponsored by the John S. and James L. Knight Foundation, AOL, Warner Bros. Entertainment, Accenture, Coca-Cola, Verizon Foundation, Intel, Weber Shandwick, and USIP. For more information on TEDxWomen, please visit the conference website at http://tedxwomen.org and download the mobile app for iPhones and Androids at http://road.ie/tedxwomen .

Reporters May Contact:
Alix Floyd, Weber Shandwick
202.585.2038
afloyd@webershandwick.com

?

SOURCE The Paley Center for Media

Source: http://news.yahoo.com/tedxwomen-2012-conference-reach-worldwide-audience-172200071.html

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Molecular knock-out alleviates Alzheimer's symptoms in mice

ScienceDaily (Nov. 30, 2012) ? Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University Medical Center G?ttingen (UMG) have identified an enzyme as a possible target for the treatment of Alzheimer's disease. The protein known as HDAC6 impairs transport processes within the nerve cells. The scientists observed only mild symptoms of the disease in mice if the enzyme was not produced. They propose to block its activity in a targeted fashion to treat the disease. Scientists from the DZNE sites in G?ttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer's disease.

The study is published in EMBO Molecular Medicine.

The researchers led by Prof. Andr? Fischer, Department of Psychiatry and Psychotherapy at the University Medical Center Gottingen and Site Speaker of the DZNE in G?ttingen, investigated mice with a modified genetic background. The animals showed behavioural disorders and brain deposits that are typically associated with Alzheimer's disease. The researchers went a step further with a group of other animals by removing the genes responsible for the production of the HDAC6 enzyme (histone deacetylase 6). This intervention proved to be effective: while these mice also exhibited the pathological features of Alzheimer's disease in the brain, their behaviour was significantly ameliorated. "The animals' ability to learn and to find their spatial bearings was relatively normal," says Prof. Fischer. "Their cognitive abilities were fully comparable to those of healthy mice."

Improved cellular traffic

In the researchers' view, this effect is at least partly attributable to the fact that important transport processes within the nerve cells are facilitated when the HDAC6 enzyme is not around. This meant in particular that the cells' power plants, also known as "mitochondria," can travel to their final destinations. "It is known that in various neurodegenerative diseases cellular transport is no longer functional. The substances that are to be transported along axons are left behind," Fischer says. "Measures which improve trafficking seem to have a positive effect."

Possible target for therapy?

The researchers' findings suggest that the HDAC6 enzyme could be a possible target for therapies against Alzheimer's disease. However, treatments would require an active substance that can disable the enzyme in a targeted fashion. Unfortunately, the active substances known to date are too unspecific. Prof. Fischer explains that their application resembles a broad-spectrum treatment: "We don't know precisely what is the therapeutic effect of the inhibitors, since they simultaneously block several enzymes from the histone deacetylase family," he says. "And we still don't know enough about how the individual enzymes function."

Improving the accuracy of the inhibitors is therefore the aim of further research. "We will continue to work toward this goal. On one hand, we want to improve our understanding of how the various histone deacetylases function. On the other hand, we want to test inhibitors that operate in a more targeted manner," says Prof. Andr? Fischer.

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The above story is reprinted from materials provided by Helmholtz Association of German Research Centres.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schl?ter, Frank Bradke, Jianrong Lu, Andr? Fischer. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Molecular Medicine, 2012; DOI: 10.1002/emmm.201201923

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ljCUFV1QTrs/121130121600.htm

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Stock Trading Information: Difference Between Trading in Forex and ...

The foreign exchange trade is also recognized as the FX market, and the forex dealing. Transacting that takes place among two areas with varied currencies is the premise for the fx market and the aspect of the trading in this business. The forex business is over thirty years old, started in the early 1970s. The forex trading is one that is not established on any one industry or investing in any one company, but the dealing and selling of currencies.

The distinction among the stock trade and the forex trading is the enormous dealing that happens on the forex market. There are millions and millions that are dealt every day in the forex market, nearly two trillion dollars are transacted every day. The total is a lot higher than the capital transacted on the customary stock market of any nation. The forex business is one that entails regimes, banks, financial organizations and those equivalent kinds of organizations from another countryside.

What is dealt, purchased and traded on the forex market is something that can readily be cashed in, meaning it can be rotated back to cash quickly, or often times it is, in fact, going to be cash. From one currency to other, the accessibility of cash in the forex trading is something that can take place rapidly for any investor from any nation.

The dissimilarity among the stock trade and the forex trading is that the forex business is worldwide, global. The stock trade is something that takes place only in a nation. The stock trade is established on industries and commodities that are in under a nation, and the forex trade takes that a move further to include any nation.

The stock trade has set the commerce hours. Mostly, this is moving to follow the trade day, and will be shut on banking leaves and weekends. The forex trade is one that is open usually twenty-four hours a day since the vast number of nations that are participating in forex dealing, purchasing and selling are positioned in so many distinctive time's zones. As one business is opening, other country's trade is shutting. This is the endless method of how the forex market dealing takes place.

The stock business in any nation is going to be established on only that state currency, say, for instance, the Japanese yen, and the Japanese stock business, or the United States stock business and the dollar. Nevertheless, in the forex trade, you are implicated in many kinds of nations, and numerous currencies. You will come upon quotations to a multiplicity of currencies, and this is a considerable distinction between the stock business and the forex business.

Manage you personal finance very carefully. Learn more about insurance, loans, share market, forex trading, mutual funds, stock market trading, etc.http://sharemarket.org.in/

Source: http://stocktradinginfo.blogspot.com/2012/11/difference-between-trading-in-forex-and.html

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APNewsBreak: Cancer agency OK'd faulty $11M grant

AUSTIN, Texas (AP) ? Leaders of Texas' embattled $3 billion cancer-fighting effort approved an $11 million grant to a biomedical company even though the proposal wasn't reviewed, according to an internal audit that deepens the troubles of a state agency that has been denounced in recent months by some of the world's top scientists.

A person with knowledge of the grant's improper approval told The Associated Press on Thursday that the discovery was uncovered during internal audit of the Cancer Prevention and Research Institute of Texas. The person spoke on condition of anonymity because the agency had not yet made an official announcement.

The award to Peloton Therapeutic Inc. in 2010 was among first ever handed out by the agency, and remains one of its largest taxpayer-funded grants to date. Tim Kutzkey, Peloton's acting chief executive officer, declined comment.

The cancer institute is home to the nation's second largest pot of cancer-research money, behind only the National Institutes of Health, and has awarded nearly $700 million. But it has come under intensifying scrutiny as several scientists, including two Nobel laureates, resigned in protest in recent months claiming the agency was charting a new politically-driven path that put commercial interests before science.

Pelton's application would have been presented to the agency's oversight committee by Jerry Cobbs, the agency's chief commercialization officer. Cobbs announced his resignation this month.

The person told AP that the oversight committee ? made up of appointees of Gov. Rick Perry and other elected state leaders ? approved the grant even though it was presented without an outside review of the proposal's scientific or business integrity.

The person told AP that funding to Peloton has been halted and that the company's application is undergoing a second review.

The revelation is the latest blow to CPRIT, which launched in 2009 to widespread acclaim among scientists and cancer survivors but has spent the past year unraveling. Dozens of scientists have resigned from the agency's peer review panels en masse in recent weeks, some of whom criticized the fund for "hucksterism" and "suspicion of favoritism" on their way out the door.

Source: http://news.yahoo.com/apnewsbreak-cancer-agency-okd-faulty-11m-grant-232006364.html

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